These services are mostly operated by Amtrak in partnerships with state departments of transportation, and are contracted to existing motor bus operators. Other bus companies, such as Greyhound, offer connecting services to Amtrak trains, but operate separate facilities, ticketing and equipment.

In Oregon, Amtrak, in conjunction with ODOT and contracting operators, operates Thruway services between Portland and Eugene, Portland and Astoria, Ontario and Coos Bay via Bend and Eugene, Albany and Newport, Redmond and Chemult via Bend, Medford and Klamath Falls, and Klamath Falls and Pasco, Wash.

In Washington, Amtrak, in conjunction with WSDOT and contracting operators, operates Thruway coaches between Seattle and Vancouver, B.C., Tacoma and Wenatchee, Omak and Wenatchee, and Seattle and Spokane. The Seattle-Spokane service continues to Boise, Idaho.

A new Thruway route is now in service from Sacramento into northern California and southern Oregon. The service, sponsored by CalTrans, connects Medford, Ashland and several California cities to Amtrak's San Jose-Oakland-Sacramento Capitols and Oakland/Sacramento-Bakerfield San Joaquin corridors.